Label-free, impedance-based biosensor technology for continuous cell monitoring – from single 16-well pilot plates to 3,072-well automated screening. Covers proliferation, cytotoxicity, migration/invasion, and imaging workflows. For cardiomyocyte contractility and electrophysiology systems, see our Cardiac RTCA Systems page.
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General Purpose RTCA Systems platforms enable continuous monitoring of live-cell behavior without labels or endpoint assays. Researchers can evaluate proliferation, cytotoxicity, migration, invasion, and cellular kinetics with higher sensitivity and reproducibility.
Monitor tumor cell proliferation and therapeutic response.
Analyze immune-cell activation and interaction dynamics.
Evaluate compound toxicity and efficacy in real time.
Characterize cellular behavior during development workflows.
Runs on standard laptop control unit with real-time numeric and graphic display.
Software modules: base v1.4.0 (free upgrade), 3D spheroid & organoid license, 21 CFR Part 11 compliance license.
Plate options: E-Plate 16, E-Plate VIEW 16, CIM-Plate 16.
Guaranteed 10-year instrument life with 7 years of supported service (Agilent Value Promise).
Immunotherapy kits validated against Daudi, Raji, Ramos, K562, MEC2, NALM6, RS4;11, RPMI 8226, HEL 92.1.7, and THP-1.
Workstation requirement: Intel Core i7 or above, 16 GB RAM, 512 GB SSD.
Single compact footprint- sits directly inside a standard CO2 incubator.
| Application / Instrument | RTCA S16 | RTCA DP | RTCA SP | RTCA MP | RTCA HT | HT–BioSpa 8 | RTCA eSight |
|---|---|---|---|---|---|---|---|
| Well format | 1 × 16 | 3 × 16 | 1 × 96 | 6 × 96 | 1 × 384 | 8 × 384 | 3 × 96 impedance / 5 × 96 imaging |
| Maximum wells | 16 | 48 | 96 | 576 | 384 (1,536 with 4 units) | 3,072 | 288 impedance / 480 imaging |
| Cell characterization / QC | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Immunotherapy / Cell Killing | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Cell Invasion / Migration | - | ✓ | - | - | - | - | - |
| Live-cell Imaging | - | - | - | - | - | - | - |
| Automated / Robotics Ready | - | - | - | - | (3rd-party) | (BioSpa 8) | - |
| Typical Use Case | Assay Development | CIM Assays / Co-culture | Routine Monitoring / Wound Healing | Multi-plate Throughput | High-Throughput Screening (HTS) | Unattended HTS | Imaging + Impedance Analysis |
Advanced live-cell analysis capabilities for cytotoxicity screening, immunotherapy research, and real-time cellular monitoring.
Used by leading institutions driving scientific progress across India and globally.
The RTCA S16 is purpose-built for assay development and optimization on a single 16-well cradle. It runs the same RTCA Software Pro used across the higher-throughput MP, SP, and HT systems, making it easy to transfer validated protocols as your workflow scales.
All three systems use label-free impedance technology with the same Cell Index readout. RTCA SP is a single 96-well station for routine experiments, RTCA MP supports up to six 96-well plates in parallel for higher throughput, while RTCA HT uses a 384-well format designed for robotics-integrated high-throughput screening with up to four HT units operating together.
Choose RTCA eSight when impedance data alone isn’t enough. It combines label-free impedance measurements with live-cell imaging, allowing analysis of co-cultures, fluorescence-based cell counting, and advanced 3D spheroid or organoid assays from the same wells during a single experiment.
The RTCA DP system, together with the CIM-Plate 16, is specifically designed for migration and invasion studies. Cells migrate through an 8 μm porous membrane toward a chemoattractant and attach to gold biosensors, providing quantitative, label-free kinetic measurements.
Yes. RTCA HT integrates with the Agilent BioTek BioSpa 8 automated incubator. Its robotic arm automatically transfers 384-well E-Plates between the incubator and analyzer, enabling unattended screening of up to eight plates (3,072 wells) while maintaining temperature, CO₂/O₂, and humidity control.
Yes. The RTCA systems listed on this page are not designed for cardiomyocyte contractility or field potential recording. Dedicated Cardiac RTCA systems such as Cardio, CardioECR, and ePacer are recommended for those applications.
No. All xCELLigence RTCA instruments, software, and consumables referenced on this page are intended For Research Use Only (RUO) and are not approved for diagnostic procedures.
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